[Published online Journal of Computer Chemistry, Japan Vol.16, 102-105, by J-STAGE]
<Title:> ポドフィリックアルデヒドの全合成における中間体の反応性の計算化学的考察
<Author(s):> 三原 陽子, 森川 大, 野村 泰志, 西井 良典
<Corresponding author E-Mill:> dmorikawa(at)shinshu-u.ac.jp
<Abstract:> The (-)-podophyllic aldehydes (Figure 1) exhibit notable antineoplastic cytotoxicity by apoptosis-inducing activities. In this study, we analyzed the selectivity mechanisms of some important reactions in the asymmetric total synthesis of (+)-podophyllic aldehydes which are enantiomers of the (-)-podophyllic aldehydes, by the molecular orbital method. As a result, it was shown that the selectivity of the Grignard reaction in compound 1 (Figure 2) is caused by steric hindrance. Furthermore, it was also indicated that the selectivity of the reduction in compound 2 1 is caused by the localization of LUMO at the reactive site, and the reduction in compounds 2 2 and 2 3 Scheme 2) does not proceed due to the steric hindrance by the trimethoxyphenyl group.
<Keywords:> Podophyllic aldehydes, Selectivity mechanism, Asymmetric total synthesis, Nucleophilic addiction, MO method
<URL:> https://www.jstage.jst.go.jp/article/jccj/16/4/16_2017-0030/_article/-char/ja/
<Title:> ポドフィリックアルデヒドの全合成における中間体の反応性の計算化学的考察
<Author(s):> 三原 陽子, 森川 大, 野村 泰志, 西井 良典
<Corresponding author E-Mill:> dmorikawa(at)shinshu-u.ac.jp
<Abstract:> The (-)-podophyllic aldehydes (Figure 1) exhibit notable antineoplastic cytotoxicity by apoptosis-inducing activities. In this study, we analyzed the selectivity mechanisms of some important reactions in the asymmetric total synthesis of (+)-podophyllic aldehydes which are enantiomers of the (-)-podophyllic aldehydes, by the molecular orbital method. As a result, it was shown that the selectivity of the Grignard reaction in compound 1 (Figure 2) is caused by steric hindrance. Furthermore, it was also indicated that the selectivity of the reduction in compound 2 1 is caused by the localization of LUMO at the reactive site, and the reduction in compounds 2 2 and 2 3 Scheme 2) does not proceed due to the steric hindrance by the trimethoxyphenyl group.
<Keywords:> Podophyllic aldehydes, Selectivity mechanism, Asymmetric total synthesis, Nucleophilic addiction, MO method
<URL:> https://www.jstage.jst.go.jp/article/jccj/16/4/16_2017-0030/_article/-char/ja/
